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Triazolam: Triazolam exposure in healthy volunteers was increased by approximately 30% when administered with oral ranitidine at a dose of 150 mg twice daily. Monitor patients for excessive or prolonged sedation. Methotrexate is partially bound to serum albumin, and toxicity may be increased because of displacement by certain drugs, such as salicylates, phenylbutazone, phenytoin, and sulfonamides. Renal tubular transport is also diminished by probenecid; use of methotrexate with this drug should be carefully monitored. What Are the Treatments for Heartburn? Use eye drops before eye ointments to allow the eye drops to enter the eye. lamivudine

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Therapeutic Equivalence-Related Terms, Pharmaceutical Equivalents generally will be coded AB if a study is submitted demonstrating bioequivalence. Cutaneous lupus erythematosus CLE and systemic lupus erythematosus SLE have been reported in patients taking PPIs, including Lansoprazole. These events have occurred as both new onset and an exacerbation of existing autoimmune disease. The majority of PPI-induced lupus erythematosus cases were CLE. February 20, 2016. Protonix pantoprazole Drug Side Effects, Interactions.

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Triple therapy: lansoprazole 30 mg is combined with 1 g of amoxicillin and 500 mg of clarithromycin given orally every 12 hours for 10 or 14 days. Most investigators recommend treatment with at least two antimicrobial agents in order to achieve eradication. Monotherapy with lansoprazole is ineffective and should be avoided. Pregnancy Category B. Reproduction studies have been performed in rats and rabbits at doses up to 160 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to ranitidine. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

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Moneam NM, el Sharaky AS, Badreldin MM. Oestrogen content of pomegranate seeds. This product may interfere with certain laboratory tests, possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this product. Pantoprazole comes as a delayed-release releases the medication in the intestine to prevent break-down of the medication by stomach acids tablet and as a delayed-release oral suspension a liquid that releases the medication in the intestine to prevent break-down of the medication by stomach acids to take by mouth.

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Advise the patient to read the FDA-approved patient labeling Medication Guide. This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. If you have reduced body stores or risk factors for reduced vitamin B12 and receive pantoprazole long-term treatment. As with all acid reducing agents, pantoprazole may lead to a reduced absorption of vitamin B12. Clinically relevant interactions of pantoprazole with other drugs with the same metabolic pathways are not expected. Therefore, when co-administered with pantoprazole, adjustment of the dosage of pantoprazole or of such drugs may not be necessary. There was also no interaction with concomitantly administered antacids. There have been postmarketing reports of increased INR and prothrombin time in patients receiving proton pump inhibitors, including pantoprazole, and warfarin concomitantly. Increases in INR and prothrombin time may lead to abnormal bleeding and even death. Patients treated with proton pump inhibitors and warfarin concomitantly should be monitored for increases in INR and prothrombin time. There have been reports of false-positive urine screening tests for tetrahydrocannabinol THC in patients receiving most proton pump inhibitors, including pantoprazole. An alternative confirmatory method should be considered to verify positive results. Heartburn: What's the Link? Taking a proton pump inhibitor such as lansoprazole may increase your risk of bone fracture in the hip, wrist, or spine. This effect has occurred mostly in people who have taken the medication long term or at high doses, and in those who are age 50 and older. It is not clear whether lansoprazole is the actual cause of an increased risk of fracture. April 9, 2017. DailyMed - PROTONIX DELAYED-RELEASE- pantoprazole sodium. Naughton, D. P. Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants. BMC. In a population PK analysis, total clearance increased with increasing bodyweight in a non-linear fashion. The total clearance also increased with increasing age only in children under 3 years of age. Protonix Yes, proton pump inhibitors, including protonix can cause a false postive for THC. NSAIDS including ibuprofen actually can cause a false positive as well.

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Caution should be used when NSAIDs and salicylates are administered concomitantly with lower doses of methotrexate. These drugs have been reported to reduce the tubular secretion of methotrexate in an animal model and may enhance its toxicity. Cheang, M. Efficacy of Listerine, Meridol and chlorhexidine mouthrinses as supplements to regular tooth cleaning measures. J Clin Periodontol. Zantac granules and effervescent tablets must be dissolved in water before you take them. Your doctor may recommend an antacid to help relieve pain. Carefully follow your doctor's directions about the type of antacid to use, and when to use it. Avoid drinking alcohol. It can increase the risk of damage to your stomach. It may take up to 8 weeks of using Zantac before your ulcer heals. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 6 weeks of treatment. Yoon, H. G. Delphinidin, a specific inhibitor of histone acetyltransferase, suppresses inflammatory signaling via prevention of NF-kappaB acetylation in fibroblast-like synoviocyte MH7A cells. Biochem. It involves inserting a small, lighted tube endoscope through the throat and into the stomach to look for abnormalities. This procedure is usually given if you are having severe or recurring symptoms of ulcers. Pantoprazole is not removed by hemodialysis. In case of overdose, treatment should be symptomatic and supportive. Heidelbaugh, J. Am Fam Physician, Oct. 1, 2003; vol 68, no 7: pp 1311-1318. Cefditoren: Proton Pump Inhibitors may decrease the serum concentration of Cefditoren. Management: If possible, avoid use of cefditoren with proton pump inhibitors PPIs. National Institute of Diabetes and Digestive and Kidney Diseases: "Heartburn, Gastroesophageal Reflux GER and Gastroesophageal Reflux Disease GERD. Pictures of Protonix Pantoprazole drug imprint information, side effects for the patient. However, chronic, lifelong therapy with proton-pump inhibitor may be appropriate. NCT00744419 Learn about warnings and precautions for the drug Protonix Pantoprazole. Get emergency medical help if you have signs of an allergic reaction to lansoprazole: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Hadipour-Jahromy, M. and Mozaffari-Kermani, R. Chondroprotective effects of pomegranate juice on monoiodoacetate-induced osteoarthritis of the knee joint of mice. Phytother. reminyl

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Do not crush or chew pantoprazole suspension. Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Amoxicillin: Lansoprazole delayed-release capsules have also been shown to have no clinically significant interaction with amoxicillin. Adjust dosage according to patient response and tolerance; continue therapy as long as necessary. 1 May require dosages of up to 240 mg daily. January 24, 2017. FDA Advisory Committee on Infant GERD Lessons Learned from. Women who are pregnant may also be told to avoid antacids that contain sodium. Those antacids can cause extra swelling. Link MP, Goorin AM, Miser AW, et al: The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. N Engl J of Med 1986; 314 No. 25: 1600-1606. ENDOCRINE SYSTEM: diabetes mellitus, glycosuria, goiter. Injection maintained or improved control of gastric acid secretion. Frelinger AL, Lee RD, Mulford DJ et al. A randomized, 2-period, crossover design study to assess the effects of dexlansoprazole, lansoprazole, esomeprazole, and omeprazole on the steady-state pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteers. J Am Coll Cardiol. Lucas, D. L. and Were, L. M. Anti-Listeria monocytogenes activity of heat-treated lyophilized pomegranate juice in media and in ground top round beef. NERVOUS SYSTEM: insomnia, anxiety, dizziness, hypertonia. Trigg, J. K. Evaluation of a eucalyptus-based repellent against Anopheles spp. in Tanzania. J Am Mosq. For patients receiving high doses of methotrexate, the terminal half-life is eight to 15 hours. Pantoprazole sodium was not found to be effective in a multicenter, randomized, double-blind, placebo-controlled, treatment-withdrawal study of 129 pediatric patients 1 through 11 months of age. Patients were enrolled if they had symptomatic GERD based on medical history and had not responded to non-pharmacologic interventions for GERD for two weeks. Patients received Pantoprazole sodium daily for four weeks in an open-label phase, then patients were randomized in equal proportion to receive Pantoprazole sodium treatment or placebo for the subsequent four weeks in a double-blind manner. Efficacy was assessed by observing the time from randomization to study discontinuation due to symptom worsening during the four-week treatment-withdrawal phase. There was no statistically significant difference between Pantoprazole sodium and placebo in the rate of discontinuation.

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Eksi, A. and Özhamamc I. Chemical composition and guide values of pomegranate juice. Lamotrigina, Mebeverina, Pantoprazol, Sildenafil, Tetrazepam, Tianeptina. F if it is stored beyond 48 hours to minimize discoloration. Injection should be discontinued as soon as the patient is able to resume treatment with PROTONIX Delayed-Release Tablets. Read the Medication Guide provided by your pharmacist before you start taking pantoprazole and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. In a clinical pharmacology study, pantoprazole 40 mg given orally once daily for 2 weeks had no effect on the levels of the following hormones: cortisol, testosterone, triiodothyronine T 3 thyroxine T 4 thyroid-stimulating hormone, thyronine-binding protein, parathyroid hormone, insulin, glucagon, renin, aldosterone, follicle-stimulating hormone, luteinizing hormone, prolactin and growth hormone. Miller Stage II or III with at least 1 of 3 symptoms typical for reflux esophagitis acid eructation, heartburn, or pain on swallowing were randomized to receive either 40 mg intravenous pantoprazole or 40 mg oral pantoprazole daily for 5 days. After the initial 5 days, all patients were treated with 40 mg oral pantoprazole daily to complete a total of 8 weeks of treatment. Symptom relief was assessed by calculating the daily mean of the sums of the average scores for these 3 symptoms and the daily mean of the average score for each of the symptoms separately. Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day. It is important to continue using this medication even if you feel well. Most people with or high pressure in the do not feel sick. Cohen SH, Gerding DN, Johnson S et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America SHEA and the infectious diseases society of America IDSA. Infect Control Hosp Epidemiol. Injection may not be compatible with products containing zinc. Following reconstitution and administration, discard any unused portion of esomeprazole solution. Lansoprazole delayed-release capsules alone or amoxicillin alone. This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. buy maxalt berlin

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Mitsubishi's high-speed digital photo printers are designed for professional and commercial use in event photography, integration into photo booths, and medical. Keep this leaflet. You may need to read it again. The clinical pharmacology of methotrexate has not been well studied in older individuals. Due to diminished hepatic and renal function as well as decreased folate stores in this population, relatively low doses should be considered, and these patients should be closely monitored for early signs of toxicity. Pharmacokinetics in patients with severe renal impairment similar to healthy individuals. Pantoprazole may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. This selection from the eMedTV library lists the standard doses of Zantac for several conditions including guidelines for children and babies.

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If they are taking ranitidine for these symptoms, they shouldn't be drinking for that reason. Mukhtar, H. Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice. People who suffered an osteoporosis-related fracture were almost twice as likely to have used a PPI for at least seven years. Using PPIs for six or fewer years wasn't linked to fracture risk. If you miss a dose of cimetidine and you are taking it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once. Keep Pantoprazole sodium and all medicines out of the reach of children. Patients with psoriasis or rheumatoid arthritis with alcoholism, alcoholic liver disease or other chronic liver disease should not receive methotrexate. Protonix suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people. This medication may rarely cause a severe intestinal condition Clostridium difficile-associated diarrhea due to a type of bacteria. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Esomeprazole sodium for injection is indicated for risk reduction of rebleeding in patients following therapeutic endoscopy for acute bleeding gastric or duodenal ulcers in adults. do femara work

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Esomeprazole is extensively metabolized in the liver by the cytochrome P450 CYP enzyme system. The metabolites of esomeprazole lack antisecretory activity. In a clinical pharmacology study, Pantoprazole sodium 40 mg given once daily for 2 weeks had no effect on the levels of the following hormones: cortisol, testosterone, triiodothyronine T 3 thyroxine T 4 thyroid-stimulating hormone TSH thyronine-binding protein, parathyroid hormone, insulin, glucagon, renin, aldosterone, follicle-stimulating hormone, luteinizing hormone, prolactin, and growth hormone. Controlled studies have been limited to 12 months of pantoprazole therapy. No controlled human data exist regarding the risk of neoplasia with methotrexate. Methotrexate has been evaluated in a number of animal studies for carcinogenic potential with inconclusive results. Although there is evidence that methotrexate causes chromosomal damage to animal somatic cells and human bone marrow cells, the clinical significance remains uncertain. Non-Hodgkin's lymphoma and other tumors have been reported in patients receiving low-dose oral methotrexate. However, there have been instances of malignant lymphoma arising during treatment with low-dose oral methotrexate, which have regressed completely following withdrawal of methotrexate, without requiring active anti-lymphoma treatment. Benefits should be weighed against the potential risk before using methotrexate alone or in combination with other drugs, especially in pediatric patients or young adults. Methotrexate causes embryotoxicity, abortion, and fetal defects in humans. It has also been reported to cause impairment of fertility, oligospermia and menstrual dysfunction in humans, during and for a short period after cessation of therapy. Kazui M, Nishiya Y, Ishizuka T, Hagihara K, Farid NA, Okazaki O, Ikeda T, Kurihara A. Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. August 18, 2016. pantoprazole, Protonix: Uses, Side Effects, and Dosage. Metabolism - After absorption, methotrexate undergoes hepatic and intracellular metabolism to polyglutamated forms which can be converted back to methotrexate by hydrolase enzymes. These polyglutamates act as inhibitors of dihydrofolate reductase and thymidylate synthetase. Small amounts of methotrexate polyglutamates may remain in tissues for extended periods. The retention and prolonged drug action of these active metabolites vary among different cells, tissues and tumors. A small amount of metabolism to 7-hydroxymethotrexate may occur at doses commonly prescribed. Accumulation of this metabolite may become significant at the high doses used in osteogenic sarcoma. The aqueous solubility of 7-hydroxymethotrexate is 3 to 5 fold lower than the parent compound. Methotrexate is partially metabolized by intestinal flora after oral administration. Store at room temperature away from moisture, heat, and light. Do not freeze the liquid medicine. What are the ingredients in PROTONIX? Fernández-Fernández FJ, Sesma P, Caínzos-Romero T et al. Intermittent use of pantoprazole and famotidine in severe hypomagnesaemia due to omeprazole. Neth J Med. Frequent heartburn also called acid or is the most common symptom of GERD. However, some adults with GERD and most children under the age of 12 do not have heartburn. Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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Not so fab. According to Dr. Marjorie Greenfield, ob-gyn and author of The Working. Sanofi Pharmaceuticals Partnership March, 2015. Kaltenbach, T. Arch Intern Med, May 8, 2006; vol 166: pp 965-971. National Institute on Drug Abuse: "Drug Facts: Is Marijuana Medicine? Atazanavir used to treat HIV-infection. Kombiglyze XR is only part of a complete program of treatment that may also include diet, exercise, weight control, blood tests, foot care, and eye care. Follow your diet, medication, and exercise routines very closely. Shawl, A. S. Humarain: a new dimeric gallic acid glycoside from Punica granatum L. bark. Aciphex, states that the Canadian results "warrant further study, as these fractures are important medical issues that can occur for a variety of reasons. Subscribe to our weekly email digest for doctor tips and insights to help you Sign up for free! REFERENCES 1. Controlling Occupation Exposure to Hazardous Drugs OSHA Work-Practice Guidelines. To apply drops, first. To avoid contamination, not touch the dropper tip or let it touch your or any other surface. Who should not take Lansoprazole delayed-release capsules? In the two trials described and in several smaller studies involving patients with moderate to severe erosive esophagitis, Lansoprazole delayed-release capsules produced healing rates similar to those shown above. Naproxen passes into milk. It is unknown if esomeprazole passes into milk. Consult your doctor before breast-feeding. clomipramine

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It helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent of the esophagus. Pantoprazole belongs to a class of drugs known as proton pump inhibitors PPIs. Pantoprazole IV Protonix IV. Yarrow is LIKELY SAFE when taken by mouth in the amounts commonly found in food. However, yarrow products that contain thujone might not be safe. Yarrow is POSSIBLY SAFE when taken by mouth in medicinal amounts. In some people, yarrow might cause drowsiness and increase urination when taken by mouth. When it comes in contact with the skin, yarrow might cause skin irritation. Use lansoprazole exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Concomitant administration of esomeprazole and tacrolimus may increase the serum levels of tacrolimus. Some medications that are changed by the liver include omeprazole Prilosec lansoprazole Prevacid and pantoprazole Protonix; diazepam Valium; carisoprodol Soma; nelfinavir Viracept; and others. Generally speaking, neither hemodialysis nor peritoneal dialysis has been shown to improve methotrexate elimination. However, effective clearance of methotrexate has been reported with acute, intermittent hemodialysis using a high-flux dialyzer Wall, SM et al: Am J Kidney Dis 28 6: 846-854, 1996. Injection each vial containing 40 mg pantoprazole. The suspension may be mixed with water and administered via nasogastric tube. Peppermint essential oil has many benefits including digestive support, pain relief and breath freshener.

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Rosenquist, H. Effect of organic acids and marination ingredients on the survival of Campylobacter jejuni on meat. No dosage adjustment of Lansoprazole delayed-release capsules is necessary in patients with renal impairment. However, the drugs Relistor and naloxegol Movantik are approved to treat specifically due to use. You should not drive or operate dangerous equipment when first taking narcotics, and you may need to avoid these activities if you take narcotics long term. Typically, your doctor will prescribe 40 mg daily for four to eight weeks of treatment. The medication should be taken around the same time each day. Lansoprazole delayed-release capsules are available in two strengths: 15 mg and 30 mg of Lansoprazole per capsule. Methotrexate-induced lung disease, including acute or chronic interstitial pneumonitis, is a potentially dangerous lesion, which may occur acutely at any time during therapy and has been reported at low doses. It is not always fully reversible and fatalities have been reported. Pulmonary symptoms especially a dry, nonproductive cough may require interruption of treatment and careful investigation. PROTONIX DELAYED-RELEASE- pantoprazole sodium granule, delayed. Kiefer, D. In the news, Pomegranate improves sperm quality. Hora JJ, Maydew ER, Lansky EP, Dwivedi C. Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice. The packets of delayed-release granules for oral suspension must be mixed with applesauce or apple juice and taken by mouth or given through a feeding tube. November 24, 2016. Can Acid Reflux Cause Throat and Ear Pain? vivitrol oral solution

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TSH, or GH. Possible impairment of vasopressin release. Do not use this medication if you are allergic to ranitidine. The following adverse reactions have been identified during postapproval use of Protonix. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Foreign studies have shown that patients heal equally well with 150 mg twice daily and 300 mg at bedtime 85% versus 84%, respectively during a usual 4-week course of therapy. If patients require extended therapy of 8 weeks, the healing rate may be higher for 150 mg twice daily as compared to 300 mg at bedtime 92% versus 87%, respectively.

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Intermittent dosing: Loading dose of 80 mg followed by either 40 mg every 12 hours for 72 hours Hung, 2007; Yamada, 2012 or 40 mg every 6 hours for 72 hours Hsu, 2009. May also administer 40 mg every 12 hours for 72 hours without a loading dose Yuksel, 2008. Harvard Mental Health Letter: "Medical Marijuana and the Mind. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects.

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Nasopharyngitis and pharyngolaryngeal pain occurred in pediatric patients between the ages of 2 to 16 years. Possible increased risk of Clostridium difficile infection; importance of contacting a clinician if persistent watery stools, abdominal pain, and fever occur. Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed. Ferreira, D. Urolithins, intestinal microbial metabolites of Pomegranate ellagitannins, exhibit potent antioxidant activity in a cell-based assay.

Important information

Open the capsule and sprinkle the medicine into a spoonful of pudding, applesauce, yogurt, cottage cheese, or strained pears. Swallow this mixture right away without chewing. Do not save the mixture for later use. Gugliucci, A. Beyond the antioxidant properties: pomegranate juice polyphenols increase hepatocyte paraoxonase 1 secretion. CNS relapse was observed in the group whose dose was based on age.

American Academy of Family Physicians: "Heartburn. Misconceptions about cataracts are common. More and more medical centers have been built specifically for cataract surgery. Marketing campaigns aimed at older adults may encourage some people to have surgery when they do not really need it. Because of fear of blindness or loss of independence, older adults may think they need to have surgery even when their cataracts do not affect their quality of life. In many cases, wearing or contacts and using other aids might be appropriate and just as effective without any of the risks of surgery. Babich, H. Pomegranate extract, a prooxidant with antiproliferative and proapoptotic activities preferentially towards carcinoma cells. Anticancer Agents Med.

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